How long does it take for Oxycodone-Acetaminophen 10-325 too get out of your system.? It really depends on your body & your body mass & how much you take a day. If you're taking Oxycodone 10/325's. I take the same dosage every 8 hours due to the fact that it does not last 12hrs for me. I have found that it takes an hour to and hour and half for it to relieve my pain. Percocet is a pain reliever that's prescribed for people with moderate to severe pain. It contains the narcotic oxycodone, an opiate analgesic medication, and acetaminophen (Tylenol), a non-narcotic pain reliever and fever reducer. Re: Why does it take so long for oxycodone to kick in? Looks like a case of (just my guess) being in a slight withdrawl state from the Hydro as your receptors have been used to that from years of taking it and now that you are switching to Oxy your body just needs a little time to adjust to this change. Does it take this long for the effects to kick in or is it a case of higher tolerance than previously thought and I would require more stuff to get a buzz. I plan on taking another one in 10 days to 15 days. As well as considering how long does Percocet last, many people may also wonder how long it stays in your system. The half life of Percocet is estimated to be around 4 hours, so to fully clear it on average will take just over 19 hours. first of all both drugs are from the oxycodone family percocet is not time release as far as i know roxicodone goes up to 30 mg and it is IR the oxycontin has a coating on it which enables it to release med in your body for long periods of time also oxycontin does not has the tylenol in it as the percocet does You should not take more than 2000 mg of tylenol daily as far as i know the perc 10. How Long Does It Take For Oxycodone To Kick In? September 13, 2017 by admin The increasing severity of oxycodone abuse has raised concern in the US about the crisis so called “Opioid epidemic,” which approximately costs over 30,000 lives of the Americans per year. My pain mgt. Doctor has me taking percocet 10/650mg three times a day as needed, which means if I am not in pain I don't take it three times a day. Usually percocet lasts 6 to 8 hours. Usually percocet lasts 6 to 8 hours.